Curcumin
 |
| Anti-inflammatory (inhibitor of NF-κB activation, inhibitor of mTOR ...), cell death “inducer” (classical apoptosis, but also mitotic catastrophe, necrosis and maybe autophagy), ~antioxidant, caloric-restriction mimetic / xenohormetic (via mTor inhibition, Nrf2 activation ?), anti-angiogenic etc!... On wikipedia, On Pubmed |
n.b. SIRT6, NF-κB and aging article
n.b. other NF-κB inhibitors: aspirin, astragaloside IV.
n.b. other mTor inhibitors: metformin, protein/methionine restriction!
n.b. Bioavailability: ? not great but has a real effect, maybe better with bioperin/piperine (black peper) that interferes with glucuronidation?
Carnosine
 |
Antioxidant, antiglycator (inhibits the formation of certain AGEs) and metal chelator. On wikipedia, On PubMed |
n.b. another anti AGE: benfotiamine
(benfotiamine (on wikipedia) a lipophilic derivative of thiamine [vitamin B1] with better bioavailability)
n.b. another anti AGE: fisetin found in strawberries c.f. PLoS one
DHA and EPA omega 3s
Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA): Natural inflammatory process controlers. Inhibit macropage inflammatory response (secretion of cytokines and other proteins that cause inflammation) via the activation of their GPR120 receptors. Might reduce / prevent chronic inflammation and its subsequent ill effects…
Why fish oils work swimmingly against diabetes
N-acetylcysteine
Nephroprotector, induced Glutathione production (major endogenous antioxidant produced by the cells)... could control the damages in Hutchinson Gilford progeria!
